This was a great post about Twisted with several great paragraphs about reading and understanding source code that ring very true. Below is a bit that I found meaningful.

Experience is multidimensional. Learning is experience, not rules. When you really jump into this stuff, it will surround you. You will have an experience of the code. For me, that is a mental experience akin to looking at something from the perspective of three dimensions versus two. When I've not dedicated myself to understanding a problem, the domain, or the tools of the domain, everything looks very flat to me. It's hard to muddle through. I feel like I have no depth perception and I get easily frustrated.

Read the whole post here.